SPECIAL 
REPORT FROM BUSINESS WEEK  
  
  
	  
		  Mechanical body parts could 
someday   
    
 
make disabilities irrelevant in the workplace
      
 
 
	  Getting a makeover is about to 
take on a whole new meaning. In the not-too-distant future, doctors will be able 
to do as much under the skin as beauticians now do on top. For the many people 
with disabilities or chronic diseases, technology is on the verge of unlocking a 
whole new world. 
 
Scattered across the globe, dozens of research teams are working on computer 
chips that will be implanted in the brain or spinal cord to give artificial 
vision to the blind, hearing to the deaf, and speech to the victims of stroke. 
Other laboratories and companies are developing products that will regulate 
bladder function for the incontinent, restore movement to the paralyzed, and 
give back muscle control to people with amyotrophic lateral sclerosis (ALS, or 
Lou Gehrig's disease). Artificial kidneys and blood vessels are being tested in 
several labs, including the McGowan Center for Artificial Organ Development at 
the University of Pittsburgh. At the University of New Mexico's Artificial 
Muscle Research Institute, scientists are developing polymer-metal composites 
that could serve as replacement muscles for patients suffering such afflictions 
as muscular dystrophy. 
 
SILICON RETINAS. Name almost any disability, and there's probably 
research under way to overcome it. Most magical of all, though, is the drive to 
restore vision in the blind. Already, Dr. Mark S. Humayun, a researcher at Johns 
Hopkins University Medical Institutions in Baltimore, has implanted 
light-sensitive chips in the eyes of some 15 patients. These tiny silicon 
retinas provide a very crude, 15-pixel image. A somewhat better, 64-pixel image 
is provided by an artificial-vision system that relays scenes from a miniature 
    video camera to a small electronic-circuit card inside the skull of Jerry, the 
blind man wearing the strange-looking eye glasses in the picture above. (He asks 
that his last name not be used.) Jerry's vision system was developed over four 
decades by William H. Dobelle, CEO of Dobelle Institute Inc. in Commack, N.Y. 
''My next version will be better still,'' he says--with 512 pixels. Still, 
that's a far cry from the hundreds of thousands of pixels on a TV screen or 
computer monitor. 
 
Image quality will keep getting better as semiconductor technology continues to 
pack silicon chips with more power. In 10 years it might be good enough that 
users will blend into the crowd. In 20 years, the acuity of artificial vision 
might rival that of a biological eye, says Dr. William J. Heetderks, head of a 
National Institutes of Health program focused on developing electronic implants. 
In fact, fully functioning artificial eyes should be ready by 2024, predicts Ian 
D. Pearson, a researcher at British Telecommunications PLC's BT Laboratories in 
England. 
 
Long before then, other manmade body parts will be helping people to overcome 
disabilities. Artificial hearing implants, offering better sound than today's 
cochlear implants, may arrive sooner--perhaps within a year. Electronic implants 
to stimulate the muscles in paralyzed limbs should be ready by 2002, says 
Pearson of BT Labs. Artificial lungs and kidneys may follow by 2015, although 
some researchers optimistically predict 2010, when a permanent artificial heart 
may be ready. 
 
Advanced prototypes of all these spare body parts already exist in research 
labs. The history of such efforts, after all, goes back almost six decades to 
the kidney dialysis machine, which was invented in 1943 in the Netherlands by 
Dr. Willem J. Kolff. Known today as the father of artificial organs, he came to 
the U.S. in 1950, developed an artificial heart at the Cleveland Clinic in the 
mid-1950s, and in the 1960s formed an artificial-organ research program at the 
University of Utah. Many others followed; Dobelle, for one, started his 
artificial vision work under Kolff's tutelage. 
 
Probably the Utah group's most famous product was the Jarvik heart, named after 
Robert K. Jarvik, who developed the original design in the late 1970s while he 
was an engineering student at Utah--building on the work of at least 147 of 
Kolff's students. Since then, mechanical-heart designs have leaped into the 
Space Age. Several of the latest versions have tiny turbines for pumping 
blood--borrowed from the turbines that pump fuel in the Space Shuttle. 
Supercomputer simulations at NASA and the Pittsburgh Supercomputing Center honed 
the turbine designs to make them superhumanly efficient. For now, these pumps 
are used only as ''bridge'' devices to sustain a patient until a human heart is 
available for transplant. But researchers are confident they'll eventually be 
permanent replacements. 
 
Moreover, artificial organs no longer need a connection through the skin to an 
outside power source. In 1991, researchers at the University of Ottawa Heart 
Institute developed a so-called inductive system that ''broadcasts'' electrical 
power through the skin. Patients can move about freely using a battery pack. A 
similar system also transmitted signals through the skin, activating an 
artificial-vision brain implant. So blind people may not need a hole in their 
head like Jerry has. 
 
Americans who want Dobelle's system may have to fly to Zurich, where he has a 
clinic. Stringent U.S. Food & Drug Administration safety rules make it 
uneconomical to introduce artificial-organ technology at home, he says. That's 
why Dr. Bartley P. Griffith, director of Pittsburgh's McGowan Center for 
Artificial Organ Development, will head to Israel to perform the first human 
implant of a new turbine heart. ''The U.S. standard is that we're not going to 
use devices that might do harm, no matter how gravely ill the patient is,'' he 
says. To Kolff, who's now 89, that doesn't make sense, and he has been lobbying 
Washington for a change. Some 95,000 people will die this year ''without a 
chance,'' he laments, because only a couple thousand donor hearts will probably 
be available. Dr. Steven J. Phillips, an assistant research director at the 
National Institutes of Health, also believes the FDA could ease up. ''Europe's 
safety record with our new devices is actually better than our own--and they're 
saving more lives,'' he notes. He also worries about so much of the research 
migrating to Europe because of its encouraging climate. 
 
Yet ultimately, most of these gadgets may be replaced. Biotech engineers will 
figure out how to tinker with genes and prevent or cure blindness, heart 
disease, and other afflictions. But it won't happen for at least 20 years, says 
Griffith. That leaves a big gap for mechanical body parts to fill. Soon, 
''making a new you'' could take on a whole new meaning. 
 
By Otis Port in New York 
  
 
 
    
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